Multiple Loci Modulate Opioid Therapy Response for Cancer
نویسندگان
چکیده
Purpose: Patients treated with opioid drugs for cancer pain experience different relief responses, raising the possibility that genetic factors play a role in opioid therapy outcome. In this study, we tested the hypothesis that genetic variations may control individual response to opioid drugs in cancer patients. Experimental Design:We tested 1million single-nucleotide polymorphisms (SNP) in European cancer patients, selected in a first series, for extremely poor (pain relief 40%; n1⁄4 145) or good (pain relief 90%; n 1⁄4 293) responses to opioid therapy using a DNA-pooling approach. Candidate SNPs identified by SNParray were genotyped in individual samples constituting DNA pools as well as in a second series of 570
منابع مشابه
Multiple Loci modulate opioid therapy response for cancer pain.
PURPOSE Patients treated with opioid drugs for cancer pain experience different relief responses, raising the possibility that genetic factors play a role in opioid therapy outcome. In this study, we tested the hypothesis that genetic variations may control individual response to opioid drugs in cancer patients. EXPERIMENTAL DESIGN We tested 1 million single-nucleotide polymorphisms (SNP) in ...
متن کاملPredictive Biomarkers and Personalized Medicine Multiple Loci Modulate Opioid Therapy Response for Cancer Pain
Purpose: Patients treated with opioid drugs for cancer pain experience different relief responses, raising the possibility that genetic factors play a role in opioid therapy outcome. In this study, we tested the hypothesis that genetic variations may control individual response to opioid drugs in cancer patients. Experimental Design:We tested 1million single-nucleotide polymorphisms (SNP) in Eu...
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